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1

Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts

Burcham, Philip C.

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 2.21 MB

english, 1998

2

Taking Pharmaceutical Innovation to the Masses

Burcham, Philip C.

Journal:

ACS Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 302 KB

english, 2017

3

Clofibrate pretreatment in mice confers resistance against hepatic lipid peroxidation

Felicity A. Nicholls-Grzemski, G. Brian Belling, Brian G. Priestly, Ian C. Calder, Philip C. Burcham

Journal:

Journal of Biochemical and Molecular Toxicology

Année:

2000

Langue:

english

Fichier:

PDF, 122 KB

english, 2000

4

A pharmacokinetic evaluation of HIV protease inhibitors, cyclic ureas, in rats and dogs

Y. Nancy Wong, Deborah L. Burcham, Philip L. Saxton, Susan Erickson-Viitanen, Mary F. Grubb, Check Y. Quon, Shiew-Mei Huang

Journal:

Biopharmaceutics & Drug Disposition

Année:

1994

Langue:

english

Fichier:

PDF, 425 KB

english, 1994

5

Extensive protein carbonylation precedes acrolein-mediated cell death in mouse hepatocytes

Philip C. Burcham, Frank Fontaine

Journal:

Journal of Biochemical and Molecular Toxicology

Année:

2001

Langue:

english

Fichier:

PDF, 350 KB

english, 2001

6

New insights into the chemical and molecular basis for acrolein toxicity

Philip C. Burcham

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 100 KB

english, 2007

7

Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products

Philip C. Burcham, Lisa M. Kaminskas, Frank R. Fontaine, Dennis R. Petersen, Simon M. Pyke

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 210 KB

english, 2002

8

Michael addition of acrolein to lysinyl and N-terminal residues of a model peptide: targets for cytoprotective hydrazino drugs

Lisa M. Kaminskas, Simon M. Pyke, Philip C. Burcham

Journal:

Rapid Communications in Mass Spectrometry

Année:

2007

Langue:

english

Fichier:

PDF, 221 KB

english, 2007

9

Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes

Suzanne M. Froscio, Andrew R. Humpage, Philip C. Burcham, Ian R. Falconer

Journal:

Environmental Toxicology

Année:

2003

Langue:

english

Fichier:

PDF, 111 KB

english, 2003

10

Cell-free protein synthesis inhibition assay for the cyanobacterial toxin cylindrospermopsin

Suzanne M. Froscio, Andrew R. Humpage, Philip C. Burcham, Ian R. Falconer

Journal:

Environmental Toxicology

Année:

2001

Langue:

english

Fichier:

PDF, 76 KB

english, 2001

11

Genotoxicity of Acyl Glucuronide Metabolites Formed from Clofibric Acid and Gemfibrozil: A Novel Role for Phase-II-Mediated Bioactivation in the Hepatocarcinogenicity of the Parent Aglycones?

Benedetta C. Sallustio, Louise A. Harkin, Maretta C. Mann, Sara J. Krivickas, Philip C. Burcham

Journal:

Toxicology and Applied Pharmacology

Année:

1997

Langue:

english

Fichier:

PDF, 87 KB

english, 1997

12

Long-Term Effects of Carvedilol or Metoprolol on Left Ventricular Function in Ischemic and Nonischemic Cardiomyopathy

Philip Green, Michael Anshelevich, Ashok Talreja, Joyce L. Burcham, Srinivas M. Ravi, Jamshid Shirani, Thierry H. Le Jemtel

Journal:

The American Journal of Cardiology

Année:

2005

Langue:

english

Fichier:

PDF, 99 KB

english, 2005

13

Toxicity of smoke extracts towards A549 lung cells: Role of acrolein and suppression by carbonyl scavengers

Philip C. Burcham, Albert Raso, Colin A. Thompson

Journal:

Chemico-Biological Interactions

Année:

2010

Langue:

english

Fichier:

PDF, 815 KB

english, 2010

14

Modified protein carbonyl assay detects oxidised membrane proteins: A new tool for assessing drug- and chemically-induced oxidative cell injury

Philip C. Burcham

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2007

Langue:

english

Fichier:

PDF, 210 KB

english, 2007

15

UDP-glucuronosyltransferase-dependent bioactivation of clofibric acid to a DNA-damaging intermediate in mouse hepatocytes

Roula Ghaoui, Benedetta C. Sallustio, Philip C. Burcham, Frank R. Fontaine

Journal:

Chemico-Biological Interactions

Année:

2003

Langue:

english

Fichier:

PDF, 285 KB

english, 2003

16

Diminished Susceptibility to Proteolysis after Protein Modification by the Lipid Peroxidation Product Malondialdehyde: Inhibitory Role for Crosslinked and Noncrosslinked Adducted Proteins

Philip C. Burcham, Yamini T. Kuhan

Journal:

Archives of Biochemistry and Biophysics

Année:

1997

Langue:

english

Fichier:

PDF, 154 KB

english, 1997

17

Introduction of Carbonyl Groups into Proteins by the Lipid Peroxidation Product, Malondialdehyde

Philip C. Burcham, Yamini T. Kuhan

Journal:

Biochemical and Biophysical Research Communications

Année:

1996

Langue:

english

Fichier:

PDF, 184 KB

english, 1996

18

Formation of Novel C1-Oxidised Abasic Sites in Alkylperoxyl Radical-Damaged Plasmid DNA

Louise A. Harkin, Philip C. Burcham

Journal:

Biochemical and Biophysical Research Communications

Année:

1997

Langue:

english

Fichier:

PDF, 77 KB

english, 1997

19

Paracetamol-induced stimulation of glycogenolysis in isolated mouse hepatocytes is not directly associated with cell death

Philip C. Burcham, Andrew W. Harman

Journal:

Biochemical Pharmacology

Année:

1989

Langue:

english

Fichier:

PDF, 756 KB

english, 1989

20

Protein alkylation, transcriptional responses and cytochrome c release during acrolein toxicity in A549 cells: Influence of nucleophilic culture media constituents

Colin A. Thompson, Philip C. Burcham

Journal:

Toxicology in Vitro

Année:

2008

Langue:

english

Fichier:

PDF, 937 KB

english, 2008

21

Prior exposure to acrolein accelerates pulmonary inflammation in influenza A-infected mice

Ferrer H.C. Ong, Peter J. Henry, Philip C. Burcham

Journal:

Toxicology Letters

Année:

2012

Langue:

english

Fichier:

PDF, 1.83 MB

english, 2012

22

Internal hazards: baseline DNA damage by endogenous products of normal metabolism

Philip C Burcham

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Année:

1999

Langue:

english

Fichier:

PDF, 250 KB

english, 1999

23

Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde

Kaminskas, Lisa M., Pyke, Simon M., Burcham, Philip C.

Journal:

Organic & Biomolecular Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2004

24

Cylindrospermopsin Genotoxicity and Cytotoxicity: Role Of Cytochrome P-450 and Oxidative Stress

Humpage, Andrew R., Fontaine, Frank, Froscio, Suzanne, Burcham, Philip, Falconer, Ian R.

Journal:

Journal of Toxicology and Environmental Health

Année:

2005

Langue:

english

Fichier:

PDF, 267 KB

english, 2005

25

An Introduction to Toxicology ||

Burcham, Philip C.

Année:

2014

Langue:

english

Fichier:

PDF, 9.37 MB

english, 2014

26

Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism

Cheah, Esther Y., Burcham, Philip C., Mann, Tracy S., Henry, Peter J.

Journal:

Biochemical Pharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2014

27

Airborne acrolein induces keratin-8 (Ser-73) hyperphosphorylation and intermediate filament ubiquitination in bronchiolar lung cell monolayers

Burcham, Philip C., Raso, Albert, Henry, Peter J.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2014

28

Mitochondrial dysfunction in paracetamol hepatotoxicity: In vitro studies in isolated mouse hepatocytes

Burcham, Philip C., Harman, Andrew W.

Journal:

Toxicology Letters

Année:

1990

Langue:

english

Fichier:

PDF, 839 KB

english, 1990

29

Effect of acetaminophen hepatotoxicity on hepatic mitochondrial and microsomal calcium contents in mice

Burcham, Philip C., Harman, Andrew W.

Journal:

Toxicology Letters

Année:

1988

Langue:

english

Fichier:

PDF, 553 KB

english, 1988

30

Carboxylic Acid Drug-Induced DNA Nicking in HEK293 Cells Expressing Human UDP-Glucuronosyltransferases: Role of Acyl Glucuronide Metabolites and Glycation Pathways

Southwood, Hamish T., DeGraaf, Yvette C., Mackenzie, Peter I., Miners, John O., Burcham, Philip C., Sallustio, Benedetta C.

Journal:

Chemical Research in Toxicology

Année:

2007

Langue:

english

Fichier:

PDF, 740 KB

english, 2007

31

Toxicology Down Under: Past Achievements, Present Realities, and Future Prospects

Burcham, Philip C.

Journal:

Chemical Research in Toxicology

Année:

2008

Langue:

english

Fichier:

PDF, 975 KB

english, 2008

32

Differences in Lysine Adduction by Acrolein and Methyl Vinyl Ketone: Implications for Cytotoxicity in Cultured Hepatocytes

Kaminskas, Lisa M., Pyke, Simon M., Burcham, Philip C.

Journal:

Chemical Research in Toxicology

Année:

2005

Langue:

english

Fichier:

PDF, 192 KB

english, 2005

33

Intermolecular Protein Cross-Linking During Acrolein Toxicity: Efficacy of Carbonyl Scavengers as Inhibitors of Heat Shock Protein-90 Cross-Linking in A549 Cells

Burcham, Philip C., Raso, Albert, Thompson, Colin, Tan, Dino

Journal:

Chemical Research in Toxicology

Année:

2007

Langue:

english

Fichier:

PDF, 740 KB

english, 2007

34

Endogenous DNA adducts: potential and paradox. [Erratum to document cited in CA119:243024]

Marnett, Lawrence J., Burcham, Philip C.

Journal:

Chemical Research in Toxicology

Année:

1994

Langue:

english

Fichier:

PDF, 84 KB

english, 1994

35

Bioactivation of Carboxylic Acid Compounds by UDP-Glucuronosyltransferases to DNA-Damaging Intermediates: Role of Glycoxidation and Oxidative Stress in Genotoxicity

Sallustio, Benedetta C., DeGraaf, Yvette C., Weekley, Josephine S., Burcham, Philip C.

Journal:

Chemical Research in Toxicology

Année:

2006

Langue:

english

Fichier:

PDF, 272 KB

english, 2006

36

Oxidative Bioactivation of Crotyl Alcohol to the Toxic Endogenous Aldehyde Crotonaldehyde: Association of Protein Carbonylation with Toxicity in Mouse Hepatocytes

Fontaine, Frank R., Dunlop, Rachael A., Petersen, Dennis R., Burcham, Philip C.

Journal:

Chemical Research in Toxicology

Année:

2002

Langue:

english

Fichier:

PDF, 182 KB

english, 2002

37

A thermospray liquid chromatography/mass spectrometry method for analysis of human urine for the major malondialdehyde-guanine adduct

Jajoo, Hemant K., Burcham, Philip C., Goda, Yukihiro, Blair, Ian A., Marnett, Lawrence J.

Journal:

Chemical Research in Toxicology

Année:

1992

Langue:

english

Fichier:

PDF, 649 KB

english, 1992

38

Genome-Wide Transcriptional Responses to Acrolein

Thompson, Colin A., Burcham, Philip C.

Journal:

Chemical Research in Toxicology

Année:

2008

Langue:

english

Fichier:

PDF, 1.49 MB

english, 2008

39

Role of G→T Transversions in the Mutagenicity of Alkylperoxyl Radicals: Induction of Alkali-Labile Sites in Bacteriophage M13mp19

Harkin, Louise A., Butler, Lisa M., Burcham, Philip C.

Journal:

Chemical Research in Toxicology

Année:

1997

Langue:

english

Fichier:

PDF, 193 KB

english, 1997

40

Response to Letter to the Editor from Professors Priestly and Moore

Burcham, Philip C.

Journal:

Chemical Research in Toxicology

Année:

2008

Langue:

english

Fichier:

PDF, 32 KB

english, 2008

41

Endogenous DNA adducts: Potential and paradox

Marnett, Lawrence J., Burcham, Philip C.

Journal:

Chemical Research in Toxicology

Année:

1993

Langue:

english

Fichier:

PDF, 2.15 MB

english, 1993

42

Potentialities and Pitfalls Accompanying Chemico-Pharmacological Strategies against Endogenous Electrophiles and Carbonyl Stress

Burcham, Philip C.

Journal:

Chemical Research in Toxicology

Année:

2008

Langue:

english

Fichier:

PDF, 513 KB

english, 2008

43

Reactivity with Tris(hydroxymethyl)aminomethane Confounds Immunodetection of Acrolein-Adducted Proteins

Burcham, Philip C., Fontaine, Frank R., Petersen, Dennis R., Pyke, Simon M.

Journal:

Chemical Research in Toxicology

Année:

2003

Langue:

english

Fichier:

PDF, 87 KB

english, 2003

44

Intermediate Filament Carbonylation During Acute Acrolein Toxicity in A549 Lung Cells: Functional Consequences, Chaperone Redistribution, and Protection by Bisulfite

Burcham, Philip C., Raso, Albert, Thompson, Colin A.

Journal:

Antioxidants & Redox Signaling

Année:

2010

Langue:

english

Fichier:

PDF, 4.43 MB

english, 2010

45

Influenza A infection attenuates relaxation responses of mouse tracheal smooth muscle evoked by acrolein

Cheah, Esther Y., Mann, Tracy S., Burcham, Philip C., Henry, Peter J.

Journal:

Biochemical Pharmacology

Année:

2015

Langue:

english

Fichier:

PDF, 1.28 MB

english, 2015

46

[Advances in Molecular Toxicology] Volume 4 || Invited Review

Burcham, Philip C.

Année:

2010

Langue:

english

Fichier:

PDF, 738 KB

english, 2010

47

Acrolein and Human Disease: Untangling the Knotty Exposure Scenarios Accompanying Several Diverse Disorders

Burcham, Philip C.

Journal:

Chemical Research in Toxicology

Année:

2016

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2016

48

Functional characterisation and application of an ex vivo perfusion-superfusion system in murine airways

Cheah, Esther Y, Mann, Tracy S, Burcham, Philip C, Henry, Peter J

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2017

Langue:

english

Fichier:

PDF, 2.72 MB

english, 2017

49

Carbonyl Scavengers as Pharmacotherapies in Degenerative Disease: Hydralazine Repurposing and Challenges in Clinical Translation

Burcham, Philip C.

Journal:

Biochemical Pharmacology

Année:

2018

Langue:

english

Fichier:

PDF, 1016 KB

english, 2018

50

[American Society of Agricultural and Biological Engineers 2007 Minneapolis, Minnesota, June 17-20, 2007 - ()] 2007 Minneapolis, Minnesota, June 17-20, 2007 - Master of Science in Agricultural Operations Management: An Online MS Degree Program at UT Martin

Timothy N Burcham,, Joey E Mehlhorn,, Barbara A Darroch,, Philip L Smartt,

Année:

2007

Fichier:

PDF, 77 KB

2007